Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare

Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm. There is a noticeable opportunity to implement a learning health care system and data-driven healthcare to make better medical decisions, better personalized predictions; and more precise discovering of risk factors and their interactions. In this research we focus on data-driven approaches for personalized medicine. We propose a research framework which emphasizes on three main phases: 1) Predictive modeling, 2) Patient subgroup analysis and 3) Treatment recommendation. Our goal is to develop novel methods for each phase and apply them in real-world applications. In the fist phase, we develop a new predictive approach based on feature representation using deep feature learning and word embedding techniques. Our method uses different deep architectures (Stacked autoencoders, Deep belief network and Variational autoencoders) for feature representation in higher-level abstractions to obtain effective and more robust features from EMRs, and then build prediction models on the top of them. Our approach is particularly useful when the unlabeled data is abundant whereas labeled one is scarce. We investigate the performance of representation learning through a supervised approach. We perform our method on different small and large datasets. Finally we provide a comparative study and show that our predictive approach leads to better results in comparison with others. In the second phase, we propose a novel patient subgroup detection method, called Supervised Biclustring (SUBIC) using convex optimization and apply our approach to detect patient subgroups and prioritize risk factors for hypertension (HTN) in a vulnerable demographic subgroup (African-American). Our approach not only finds patient subgroups with guidance of a clinically relevant target variable but also identifies and prioritizes risk factors by pursuing sparsity of the input variables and encouraging similarity among the input variables and between the input and target variables. Finally, in the third phase, we introduce a new survival analysis framework using deep learning and active learning with a novel sampling strategy. First, our approach provides better representation with lower dimensions from clinical features using labeled (time-to-event) and unlabeled (censored) instances and then actively trains the survival model by labeling the censored data using an oracle. As a clinical assistive tool, we propose a simple yet effective treatment recommendation approach based on our survival model. In the experimental study, we apply our approach on SEER-Medicare data related to prostate cancer among African-Americans and white patients. The results indicate that our approach outperforms significantly than baseline models

SAFS: A Deep Feature Selection Approach for Precision Medicine

In this paper, we propose a new deep feature selection method based on deep architecture. Our method uses stacked auto-encoders for feature representation in higher-level abstraction. We developed and applied a novel feature learning approach to a specific precision medicine problem, which focuses on assessing and prioritizing risk factors for hypertension (HTN) in a vulnerable demographic subgroup (African-American). Our approach is to use deep learning to identify significant risk factors affecting left ventricular mass indexed to body surface area (LVMI) as an indicator of heart damage risk. The results show that our feature learning and representation approach leads to better results in comparison with others

SUBIC: A Supervised Bi-Clustering Approach for Precision Medicine

Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researchers to develop new approaches to subgroup detection and analysis, which is an effective strategy to personalize treatment. In this study, we propose a novel patient subgroup detection method, called Supervised Biclustring (SUBIC) using convex optimization and apply our approach to detect patient subgroups and prioritize risk factors for hypertension (HTN) in a vulnerable demographic subgroup (African-American). Our approach not only finds patient subgroups with guidance of a clinically relevant target variable but also identifies and prioritizes risk factors by pursuing sparsity of the input variables and encouraging similarity among the input variables and between the input and target variable

A Novel Two-level Causal Inference Framework for On-road Vehicle Quality Issues Diagnosis

In the automotive industry, the full cycle of managing in-use vehicle quality issues can take weeks to investigate. The process involves isolating root causes, defining and implementing appropriate treatments, and refining treatments if needed. The main pain-point is the lack of a systematic method to identify causal relationships, evaluate treatment effectiveness, and direct the next actionable treatment if the current treatment was deemed ineffective. This paper will show how we leverage causal Machine Learning (ML) to speed up such processes. A real-word data set collected from on-road vehicles will be used to demonstrate the proposed framework. Open challenges for vehicle quality applications will also be discussed.Comment: Accepted by NeurIPS 2022 Workshop on Causal Machine Learning for Real-World Impact (CML4Impact 2022

Intensifying to Cease: Unpacking the Process of Information Systems Discontinuance

Legacy information systems consume a large portion of information technology budgets and often impose serious limitations on organizations’ flexibility and innovation. Despite the extensive literature on how organizations adopt and use new IS, we know little about how organizations discontinue their legacy IS. Current studies suggest some actions and events to cease mechanisms such as legitimization, learning, and routinization that give continuity to the systems. However, we do not know when these actions emerge in the discontinuance process to gradually reduce the organizational commitments to legacy IS, nor do we know how ceasing one mechanism can facilitate or, conversely, hamper ceasing other mechanisms, especially when these systems involve interdependences between various components. Based on a process analysis of four software companies, we show that, contrary to the current literature, IS discontinuance is not a matter of merely ceasing each and every mechanism of an established IS; rather, it often requires that some mechanisms be temporarily intensified to prevent premature discontinuance and enable subsequent cessation of other mechanisms. Through cross-case analysis, we articulate a set of causal mechanisms that expands our understanding of how the discontinuance process can be differently shaped by organizational commitments and interdependences involved in legacy IS